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Scand J Gastroenterol (2014) 49(6):681–9.10.3109/00365521.2014.898326 14 WorthingtonJJ
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The integration of all three pathways is proposed to create a complementary pharmacological profile: appetite suppression and improved insulin secretion from GLP-1 and GIP agonism, combined with enhanced energy expenditure and hepatic lipid metabolism from glucagon receptor activation